ETRL publications

The ETRL performs research to provide the scientific evidence required for new policies and recommendations regarding histocompatibility within Eurotransplant. This research is being published in well-recognised international peer-reviewed journals. Below is a list of work published by the ETRL.


  1. Cynthia S. M. Kramer, Johan Koster, Geert W. Haasnoot, Dave L. Roelen, Frans H. J. Claas, Sebastiaan Heidt: HLA-EMMA: a user-friendly tool to analyse HLA class I and class II compatibility on the amino acid level. HLA, 2020; 96(1): 43-51
  2. Frans H.J. Claas, Sebastiaan Heidt: Virtual crossmatching for deceased donor transplantation becomes reality. Kidney International, 2020; 97(4): 657-659
  3. Sebastiaan Heidt, Frans H.J. Claas: Not all HLA epitope mismatches are equal. Kidney International, 2020; 97(4): 653-655
  4. Cynthia S. M. Kramer, Marry E. I. Franke-van Dijk, Kim H. Bakker, Merve Uyar-Mercankaya, Gonca E. Karahan, Dave L. Roelen, Frans H. J. Claas, Sebastiaan Heidt: Generation and reactivity analysis of human recombinant monoclonal antibodies directed against epitopes on HLA-DR. American Journal of Transplantation, 2020;
  5. Lisa Mumford, Susan V. Fuggle, Jaume Martorell, Antonij Slavcev, Aliki Iniotaki, Geert W. Haasnoot, Sebastiaan Heidt, Frans H.J. Claas: A Europe wide acceptable mismatch program will enable transplantation of long waiting highly sensitised patients with a compatible donor. Transplant Immunology, 2020; 64
  6. 2019

  7. Sebastiaan Heidt, Geert W. Haasnoot, Marian D. Witvliet, Marissa J. H. Linden-van Oevelen, Elena G. Kamburova, Bram W. Wisse, Irma Joosten, Wil A. Allebes, Arnold Meer, Luuk B. Hilbrands, Marije C. Baas, Eric Spierings, Cornelis E. Hack, Franka E. Reekum, Arjan D. Zuilen, Marianne C. Verhaar, Michiel L. Bots, Adriaan C. A. D. Drop, Loes Plaisier, Marc A. J. Seelen, Jan-Stephan Sanders: Allocation to highly sensitized patients based on acceptable mismatches results in low rejection rates comparable to nonsensitized patients. American Journal of Transplantation, 2019; 19(10): 2926-2933
  8. Mian Chen, Yvonne Zoet, Dave Roelen, Jaume Martorell, Derek Middleton, Antonij Slavcev, Aliki Iniotaki, Frans Claas, Susan Fuggle: Towards uniformity in the definition of acceptable mismatches for highly sensitized patients. HLA, 2019; 94(2): 147-153
  9. Cynthia S.M. Kramer, Moshe Israeli, Arend Mulder, Ilias I.N. Doxiadis, Geert W. Haasnoot, Sebastiaan Heidt, Frans H.J. Claas: The long and winding road towards epitope matching in clinical transplantation. Transplant International, 2019; 32(1): 16-24
  10. Cynthia Kramer, Sebastiaan Heidt, Frans H.J. Claas: Towards the identification of the relative immunogenicity of individual HLA antibody epitopes. Human Immunology, 2019; 80(4): 218-220
  11. Kramer, C. S. M., Franke-van Dijk, M. E. I., Priddey, A. J., Pongracz, T., Gnudi, E., Car, H., Karahan, G. E., van Beelen, E., Zilvold-van den Oever, C. C. C., Rademaker, H. J., de Haan, N., Wuhrer, M., Kosmoliaptsis, V., Parren, P. W. H. I., Mulder, A., Roelen, D. L., Claas, F. H. J., Heidt, S.: Recombinant human monoclonal HLA antibodies of different IgG subclasses recognising the same epitope: Excellent tools to study differential effects of donor-specific antibodies. HLA, 2019; 94(5): 415-424
  12. 2018

  13. Sebastiaan Heidt, Geert W. Haasnoot, Jon J. van Rood, Marian D. Witvliet, Frans H.J. Claas: Kidney allocation based on proven acceptable antigens results in superior graft survival in highly sensitized patients. Kidney International, 2018; 93(2): 491-500
  14. Sebastiaan Heidt, Geert W. Haasnoot, Frans H.J. Claas: How the definition of acceptable antigens and epitope analysis can facilitate transplantation of highly sensitized patients with excellent long-term graft survival. Current Opinion in Organ Transplantation, 2018; 23(4): 493-499
  15. Sebastiaan Heidt, Frans H.J. Claas: Transplantation in highly sensitized patients: challenges and recommendations. Expert Review of Clinical Immunology, 2018; 14(8): 673-679
  16. 2017

  17. Frans H.J. Claas, Sebastiaan Heidt: Epitope-Based HLA Matching: A Useful Strategy With Many Shortcomings to Overcome. Transplantation, 2017; 101(8): 1744-1745
  18. C. S. M. Kramer, D. L. Roelen, S. Heidt, F. H. J. Claas: Defining the immunogenicity and antigenicity of HLA epitopes is crucial for optimal epitope matching in clinical renal transplantation. HLA, 2017; 90(1): 5-16
  19. 2015

  20. Sebastiaan Heidt, Marian D. Witvliet, Geert W. Haasnoot, Frans H.J. Claas: The 25th anniversary of the Eurotransplant Acceptable Mismatch program for highly sensitized patients. Transplant Immunology, 2015; 3351-57
  21. 2011

  22. Y. M. Zoet, S. H. Brand-Schaaf, D. L. Roelen, A. Mulder, F. H. J. Claas, I. I. N. Doxiadis: Challenging the golden standard in defining donor-specific antibodies: does the solid phase assay meet the expectations?. Tissue Antigens, 2011; 77(3): 225-228
  23. 2010

  24. Ilias IN Doxiadis, Dave Roelen, Frans HJ Claas: Mature wines are better: CDC as the leading method to define highly sensitized patients. Current Opinion in Organ Transplantation, 2010; 15(6): 716-719
  25. Doxiadis,, II, Rahmel, A., Claas, F. H.: Towards kidney allocation on basis of HLA-DR compatibility. Clin Transpl, 2010; 61-64
  26. Frans HJ Claas: Clinical relevance of circulating donor-specific {HLA. Current Opinion in Organ Transplantation, 2010; 15(4): 462-466
  27. 2009

  28. Frans HJ Claas, Ilias IN Doxiadis: Management of the highly sensitized patient. Current Opinion in Immunology, 2009; 21(5): 569-572
  29. Ilias IN Doxiadis, Frans HJ Claas: Transplantation of highly sensitized patients via the acceptable mismatch program or desensitization? We need both. Current Opinion in Organ Transplantation, 2009; 14(4): 410-413
  30. Frans H. J. Claas, Axel Rahmel, IIias I. N. Doxiadis: Enhanced Kidney Allocation to Highly Sensitized Patients by the Acceptable Mismatch Program. Transplantation, 2009; 88(4): 447-452
  31. 2008

  32. Frans H. J. Claas: HLA antibody testing: a tool to facilitate not to prevent organ transplantation. International Journal of Immunogenetics, 2008; 35(4): 275-277
  33. 2007

  34. C. Eijsink, Y. M. Zoet, M. J. Kardol, M. D. Witvliet, F. H. J. Claas, A. Mulder, I. I. N. Doxiadis: Identification of acceptable {HLA. Tissue Antigens, 2007; 69(4): 354-357
  35. Ilias I. N. Doxiadis, Johan W. de Fijter, Marko J. K. Mallat, Geert W. Haasnoot, Jan Ringers, Guido G. Persijn, Frans H. J. Claas: Simpler and equitable allocation of kidneys from postmortem donors primarily based on full HLA-DR compatibility. Transplantation, 2007; 83(9): 1207-1213
  36. 2006

  37. Frans H.J. Claas, Dave L. Roelen, Arend Mulder, Ilias I.N. Doxiadis, Machteld Oudshoorn, Martin Heemskerk: Differential immunogenicity of HLA class I alloantigens for the humoral versus the cellular immune response: towards tailor-made HLA mismatching. Human Immunology, 2006; 67(6): 424-429
  38. Ilias I. N. Doxiadis, Frans H. J. Claas: Donor-Specific Antibodies Arising after Kidney Transplantectomy: Priming or Memory?. Transplantation, 2006; 81(4): 509-510
  39. 2005

  40. Ilias IN Doxiadis, Rene J Duquesnoy, Frans HJ Claas: Extending options for highly sensitized patients to receive a suitable kidney graft. Current Opinion in Immunology, 2005; 17(5): 536-540
  41. Frans H.J. Claas, Marlies K. Dankers, Machteld Oudshoorn, Jon J. van Rood, Arend Mulder, Dave L. Roelen, Rene J. Duquesnoy, Ilias I.N. Doxiadis: Differential immunogenicity of HLA mismatches in clinical transplantation. Transplant Immunology, 2005; 14(3): 187-191
  42. Yvonne M. Zoet, Chantal Eijsink, Marrie J. Kardol, Marry E.I. Franke-van Dijk, G. Louis Wilson, Roel de Paus, Eric Mickelson, Mirjam Heemskerk, Peter J. van den Elsen, Frans H.J. Claas, Arend Mulder, Ilias I.N. Doxiadis: The single antigen expressing lines (SALs) concept: an excellent tool for screening for HLA-specific antibodies. Human Immunology, 2005; 66(5): 519-525
  43. Frans HJ Claas: Transplantation: changing dogmas in clinical transplantation immunology. Current Opinion in Immunology, 2005; 17(5): 533-535
  44. Yvonne M. Zoet, Chantal Eijsink, Radka Bohmova, Marian D. Witvliet, Marrie J. Kardol, Marry E. I. Franke, Frans H. J. Claas, Arend Mulder, Ilias I. N. Doxiadis: Single-Antigen-Expressing Cell Lines Are Excellent Tools for Detecting Human Leukocyte Antigen-C???Reactive Antibodies in Kidney Transplant Recipients. Transplantation, 2005; 79(9): 1268-1272
  45. 2004

  46. Ilias I. N. Doxiadis, Jacqueline M. A. Smits, Guido G. Persijn, Ulrich Frei, Frans H. J. Claas: It takes six to boogie: Allocating cadaver kidneys in eurotransplant. Transplantation, 2004; 77(4): 615-617
  47. Frans H. J. Claas, Marian D. Witvliet, Rene Duquesnoy, Guido G. Persijn, Ilias I. N. Doxiadis: The Acceptable Mismatch Program as a Fast Tool for Highly Sensitized Patients Awaiting a Cadaveric Kidney Transplantation: Short Waiting Time and Excellent Graft Outcome. Transplantation Journal, 2004; 78(2): 190-193
  48. Marlies K.A Dankers, Dave L Roelen, Nico J.D Nagelkerke, Peter de Lange, Guido G Persijn, Ilias I.N Doxiadis, Frans H.J Claas: The HLA-DR phenotype of the responder is predictive of humoral response against HLA class I antigens. Human Immunology, 2004; 65(1): 13-19
  49. Marlies K. A. Dankers, Marian D. Witvliet, Dave L. Roelen, Peter De Lange, Nelleke Korfage, Guido G. Persijn, Ren{\'{e: The number of amino acid triplet differences between patient and donor is predictive for the antibody reactivity against mismatched human leukocyte antigens. Transplantation, 2004; 77(8): 1236-1239
  50. 2003

  51. Marlies K.A. Dankers, Dave L. Roelen, Ellen M.W. van der Meer-Prins, Peter de Lange, Nelleke Korfage, Jacqueline M.A. Smits, Guido G. Persijn, Ken I. Welsh, Ilias I.N. Doxiadis, Frans H.J. Claas: Differential immunogenicity of HLA mismatches: HLA-A2 versus HLA-A28. Transplantation, 2003; 75(3): 418-420
  52. Doxiadis,, II, Persijn, G. G., Claas, F. H.: The crossmatch policy of the transplantation center influences graft survival in cadaver kidney transplantation. Clin Transpl, 2003; 143-147
  53. 2000

  54. Doxiadis,, II, Witvliet, M., Verduyn, W., de Lange, P., Tanke, J., Schreuder, G. M., Persijn, G. G., Claas, F. H.: The relevance of proficiency testing for laboratories involved in cadaveric organ transplantation and its consequences for graft survival. Clin Transpl, 2000; 99-103
  55. 1999

  56. Claas, F. H., De Meester, J., Witvliet, M. D., Smits, J. M., Persijn, G. G., Doxiadis,, II: Acceptable HLA mismatches for highly immunized patients. Rev Immunogenet, 1999; 1(3): 351-358
  57. 1996

  58. Ilias IN Doxiadis, Jacqueline MA Smits, Geziena M Th Schreuder, Guido G Persijn, Hans C van Houwelingen, Jon J van Rood, Frans HJ Claas: Association between specific HLA combinations and probability of kidney allograft loss: the taboo concept. The Lancet, 1996; 348(1931): 850-853
  59. 1989

  60. F. H. J. Claas, A. van Leeuwen, J. J. van Rood: Hyperimmunized patients do not need to wait for an HLA identical donor. Tissue Antigens, 1989; 34(10): 23-29
  61. Claas, F. H., van Rood, J. J.: Transplantation in hyperimmunized patients. Adv Nephrol Necker Hosp, 1989; 18317-323
  62. Frans H.J. Claas, Gijbels, Y., von Veen, A., de Waal, L. P., DAmaro, J., Persijn, G. G., van Rood, J. J.: Selection of cross-match negative HLA-A and/or -B mismatched donors for highly sensitized patients. Transplantation Proceedings, 1989; 21(1): 665-666
  63. Frans H.J. Claas, de Waal, L. P., Beelen, J., Reekers, P., Berg-Loonen, P. V., de Gast, E., DAmaro, J., Persijn, G. G., Zantvoort, F., van Rood, J. J.: Transplantation of highly sensitized patients on the basis of acceptable HLA-A and B mismatches. Clin Transpl, 1989; 185-190
  64. 1988

  65. F. Claas, Y Gijbels, J van der Velden-de Munck, J. van Rood: Induction of B cell unresponsiveness to noninherited maternal HLA antigens during fetal life. Science, 1988; 241(4874): 1815-1817
  66. Frans H. J. Claas, Jon J. Rood: The hyperimmunized patient: from sensitization toward transplantation. Transplant International, 1988; 1(2): 53-57
  67. Claas, F. H., Gijbels, Y., van der Velden-de Munck, J. J., de Waal, L. P., DAmaro, J., Hendriks, G. F., Persijn, G. G., van Rood, J. J.: A special strategy to increase the chance of finding cross-match negative kidneys for highly sensitized patients. Transplantation Proceedings, 1988; 20(5): 947-948
  68. 1986

  69. Schreuder, G. M., Hendriks, G. F., DAmaro, J., Persijn, G. G.: An eight-year study of HLA typing proficiency in Eurotransplant. Tissue Antigens, 1986; 27(3): 131-141
  70. 1985

  71. Hendriks, G. F., de Lange, P., DAmaro, J., Schreuder, G. M., Claas, F. H., Persijn, G. G., van Rood, J. J.: Eurotransplant experience with highly immunized patients. Scand J Urol Nephrol Suppl, 1985; 9281-86