Eurotransplant is transitioning to the virtual donor center crossmatch. In order to do so, an extension to the current level of HLA typing is necessary. The current loci that are mandatory to type will be extended with HLA-DQA1, HLA-DPB1 and HLA-DPA1. Also, to be able to perform virtual crossmatching on HLA antibody data that is gathered at the allele level, donor HLA typing needs to reach second field level also. Since this is not yet feasible during deceased donor procedures, a temporary situation of using intermediate resolution HLA typing data is required.
The TTAC has approved new HLA tables which are to be used for the conversion of allele level HLA typing to ET Match Determinants. The tables also indicate which alleles can be entered into the ET system, and which alleles must be detectable (with or without ambiguities) by the technique that is to be used during deceased donor procedures.