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ETRL Publications

The ETRL performs research to provide the scientific evidence required for new policies and recommendations regarding histocompatibility within Eurotransplant. This research is being published in well-recognised international peer-reviewed journals. Below is a list of work published by the ETRL.

2025

  1. Gonca E. Karahan, Geert W. Haasnoot, Sebastiaan Heidt: Equitable allocation through human leukocyte antigen eplet matching: A promising strategy with several challenges. American Journal of Transplantation, 2025; 25(6):1149-1151. doi: https://doi.org/10.1016/j.ajt.2025.01.028
  2. van den Broek DAJ, Karahan GE, Meziyerh S, de Vaal Y, Bakker KH, Haasnoot GW, Rotmans JI, Teng YKO, van Kooten C, Heidt S, Roelen DL, de Vries APJ. Belimumab to Aid Pre-Transplant Immunological Risk-Stratification by Uncovering Broader HLA-Specific Memory B-Cell Profiles. HLA. 2025 Jun;105(6):e70285. doi: https://doi.org/10.1111/tan.70285.

2024

  1. Cynthia S.M. Kramer, Suzanne Bezstarosti, Marry E. I. Franke-van Dijk, Manon Vergunst, Dave L. Roelen, Merve Uyar-Mercankaya, Kim H Voogt-Bakker, Sebastiaan Heidt: Antibody verification of HLA class I and class II eplets by human monoclonal HLA antibodies. HLA, 2024; 103(1). doi: https://doi.org/10.1111/tan.15345
  2. Sebastiaan Heidt, Cynthia S.M. Kramer, Geert W. Haasnoot, Alexander H. Schmidt, Yvonne M. Zoet, Frans H.J. Claas, Serge Vogelaar: Introduction of the donor centre virtual crossmatch in Eurotransplant. HLA, 2024; 104(2). doi: https://doi.org/10.1111/tan.15653
  3. Zoet YM, Heidt S, van der Linden-van Oevelen MJH, Haasnoot GW and Claas FHJ (2024) Proficiency testing within Eurotransplant. Front. Genet. 15:1451748. doi: 10.3389/fgene.2024.1451748

2023

  1. de Ferrante H, Smeulders B, Tieken I, Heidt S, Haasnoot GW, Claas FHJ, Vogelaar S, Spieksma F. Immunized Patients Face Reduced Access to Transplantation in the Eurotransplant Kidney Allocation System. Transplantation. 2023 Oct 1;107(10):2247-2254. doi: 10.1097/TP.0000000000004687
  2. de Fijter J, Dreyer G, Mallat M, Budde K, Pratschke J, Klempnauer J, Zeier M, Arns W, Hugo C, Rump LC, Hauser I, Schenker P, Schiffer M, Grimm MO, Kliem V, Olbricht CJ, Pisarski P, Banas B, Suwelack B, Hakenberg O, Berlakovich G, Schneeberger S, van de Wetering J, Berger S, Bemelman F, Kuypers D, Heidt S, Rahmel A, Claas F, Peeters P, Oberbauer R, Heemann U, Krämer BK; Eurotransplant Senior DR-compatible Program (ESDP) Study Group. A paired-kidney allocation study found superior survival with HLA-DR compatible kidney transplants in the Eurotransplant Senior Program. Kidney Int. 2023 Sep;104(3):552-561. doi: 10.1016/j.kint.2023.05.025.

2022

  1. Suzanne Bezstarosti, Cynthia S.M. Kramer, Frans H.J. Claas, Hans W. de Fijter, Marlies E.J. Reinders, Sebastiaan Heidt: Implementation of molecular matching in transplantation requires further characterization of both immunogenicity and antigenicity of individual HLA epitopes. Human Immunology, 2022; 83(3): 256-263. doi: https://doi.org/10.1016/j.humimm.2021.12.002
  2. Suzanne Bezstarosti, Kim H. Bakker, Cynthia C.M. Kramer, Hans W. de Fijter, Marlies E.J. Reinders, Arend Mulder, Frans H.J. Claas, Sebastiaan Heidt: A comprehensive evaluation of the antibody-verified status of eplets listed in the HLA Epitope Registry. Frontiers in Immunology, 2022; 12. doi: https://doi.org/10.3389/fimmu.2021.800946
  3. Zecher D, Zeman F, Drasch T, Tieken I, Heidt S, Haasnoot GW, Vogelaar S, Rahmel A, Banas B. Impact of Sensitization on Waiting Time Prior to Kidney Transplantation in Germany. Transplantation. 2022 Dec 1;106(12):2448-2455. doi: 10.1097/TP.0000000000004238.

2021

  1. Sebastiaan Heidt, Geert W. Haasnoot, Marissa J. H. Linden-van Oevelen, Frans H.J. Claas: Highly Sensitized Patients Are Well Served by Receiving a Compatible Organ Offer Based on Acceptable Mismatches. Frontiers in Immunology, 2021; 12. doi: https://doi.org/10.3389/fimmu.2021.687254
  2. Suzanne Bezstarosti, Cynthia S.M. Kramer, Marry E.I. Franke-van Dijk, Manon Vergunst, Kim H. Bakker, Merve Uyar-Mercankaya, Rico Buchli, Dave L. Roelen, Hans W. de Fijter, Frans H.J. Claas, Sebastiaan Heidt: HLA-DQ-specific recombinant human monoclonal antibodies allow for in-depth analysis of HLA-DQ epitopes. Frontiers in Immunology, 2021; 12. doi: https://doi.org/10.3389/fimmu.2021.761893

2020

  1. Cynthia S. M. Kramer, Johan Koster, Geert W. Haasnoot, Dave L. Roelen, Frans H. J. Claas, Sebastiaan Heidt: HLA-EMMA: a user-friendly tool to analyse HLA class I and class II compatibility on the amino acid level. HLA, 2020; 96(1): 43-51. doi: https://doi.org/10.1111/tan.13883
  2. Frans H.J. Claas, Sebastiaan Heidt: Virtual crossmatching for deceased donor transplantation becomes reality. Kidney International, 2020; 97(4): 657-659. doi: https://doi.org/10.1016/j.kint.2020.01.024
  3. Sebastiaan Heidt, Frans H.J. Claas: Not all HLA epitope mismatches are equal. Kidney International, 2020; 97(4): 653-655. doi: https://doi.org/10.1016/j.kint.2019.12.017
  4. Cynthia S. M. Kramer, Marry E. I. Franke-van Dijk, Kim H. Bakker, Merve Uyar-Mercankaya, Gonca E. Karahan, Dave L. Roelen, Frans H. J. Claas, Sebastiaan Heidt: Generation and reactivity analysis of human recombinant monoclonal antibodies directed against epitopes on HLA-DR. American Journal of Transplantation, 2020. doi: https://doi.org/10.1111/ajt.15950
  5. Lisa Mumford, Susan V. Fuggle, Jaume Martorell, Antonij Slavcev, Aliki Iniotaki, Geert W. Haasnoot, Sebastiaan Heidt, Frans H.J. Claas: A Europe wide acceptable mismatch program will enable transplantation of long waiting highly sensitised patients with a compatible donor. Transplant Immunology, 2020; 64. doi: https://doi.org/10.1016/j.trim.2020.101354

2019

  1. Sebastiaan Heidt, Geert W. Haasnoot, Marian D. Witvliet, Marissa J. H. Linden-van Oevelen, Elena G. Kamburova, Bram W. Wisse, Irma Joosten, Wil A. Allebes, Arnold Meer, Luuk B. Hilbrands, Marije C. Baas, Eric Spierings, Cornelis E. Hack, Franka E. Reekum, Arjan D. Zuilen, Marianne C. Verhaar, Michiel L. Bots, Adriaan C. A. D. Drop, Loes Plaisier, Marc A. J. Seelen, Jan-Stephan Sanders: Allocation to highly sensitized patients based on acceptable mismatches results in low rejection rates comparable to nonsensitized patients. American Journal of Transplantation, 2019; 19(10): 2926-2933. doi: https://doi.org/10.1111/ajt.15486
  2. Mian Chen, Yvonne Zoet, Dave Roelen, Jaume Martorell, Derek Middleton, Antonij Slavcev, Aliki Iniotaki, Frans Claas, Susan Fuggle: Towards uniformity in the definition of acceptable mismatches for highly sensitized patients. HLA, 2019; 94(2): 147-153. doi: https://doi.org/10.1111/tan.13607
  3. Cynthia S.M. Kramer, Moshe Israeli, Arend Mulder, Ilias I.N. Doxiadis, Geert W. Haasnoot, Sebastiaan Heidt, Frans H.J. Claas: The long and winding road towards epitope matching in clinical transplantation. Transplant International, 2019; 32(1): 16-24. doi: https://doi.org/10.1111/tri.13362
  4. Cynthia Kramer, Sebastiaan Heidt, Frans H.J. Claas: Towards the identification of the relative immunogenicity of individual HLA antibody epitopes. Human Immunology, 2019; 80(4): 218-220. doi: https://doi.org/10.1016/j.humimm.2019.02.002
  5. Kramer, C. S. M., Franke-van Dijk, M. E. I., Priddey, A. J., Pongracz, T., Gnudi, E., Car, H., Karahan, G. E., van Beelen, E., Zilvold-van den Oever, C. C. C., Rademaker, H. J., de Haan, N., Wuhrer, M., Kosmoliaptsis, V., Parren, P. W. H. I., Mulder, A., Roelen, D. L., Claas, F. H. J., Heidt, S.: Recombinant human monoclonal HLA antibodies of different IgG subclasses recognising the same epitope: Excellent tools to study differential effects of donor-specific antibodies. HLA, 2019; 94(5): 415-424. doi: https://doi.org/10.1111/tan.13664

2018

  1. Sebastiaan Heidt, Geert W. Haasnoot, Jon J. van Rood, Marian D. Witvliet, Frans H.J. Claas: Kidney allocation based on proven acceptable antigens results in superior graft survival in highly sensitized patients. Kidney International, 2018; 93(2): 491-500. doi: https://doi.org/10.1016/j.kint.2017.07.018
  2. Sebastiaan Heidt, Geert W. Haasnoot, Frans H.J. Claas: How the definition of acceptable antigens and epitope analysis can facilitate transplantation of highly sensitized patients with excellent long-term graft survival. Current Opinion in Organ Transplantation, 2018; 23(4): 493-499. doi: https://doi.org/10.1097/MOT.0000000000000545
  3. Sebastiaan Heidt, Frans H.J. Claas: Transplantation in highly sensitized patients: challenges and recommendations. Expert Review of Clinical Immunology, 2018; 14(8): 673-679. doi: https://doi.org/10.1080/1744666X.2018.1498335

2017

  1. Frans H.J. Claas, Sebastiaan Heidt: Epitope-Based HLA Matching: A Useful Strategy With Many Shortcomings to Overcome. Transplantation, 2017; 101(8): 1744-1745. doi: https://doi.org/10.1097/tp.0000000000001705
  2. C. S. M. Kramer, D. L. Roelen, S. Heidt, F. H. J. Claas: Defining the immunogenicity and antigenicity of HLA epitopes is crucial for optimal epitope matching in clinical renal transplantation. HLA, 2017; 90(1): 5-16. doi: https://doi.org/10.1111/tan.13038

2015

  1. Sebastiaan Heidt, Marian D. Witvliet, Geert W. Haasnoot, Frans H.J. Claas: The 25th anniversary of the Eurotransplant Acceptable Mismatch program for highly sensitized patients. Transplant Immunology, 2015; 3351-57. doi: https://doi.org/10.1016/j.trim.2015.08.006

2011

  1. Y. M. Zoet, S. H. Brand-Schaaf, D. L. Roelen, A. Mulder, F. H. J. Claas, I. I. N. Doxiadis: Challenging the golden standard in defining donor-specific antibodies: does the solid phase assay meet the expectations?. Tissue Antigens, 2011; 77(3): 225-228. doi: https://doi.org/10.1111/j.1399-0039.2010.01608.x

2010

  1. Ilias IN Doxiadis, Dave Roelen, Frans HJ Claas: Mature wines are better: CDC as the leading method to define highly sensitized patients. Current Opinion in Organ Transplantation, 2010; 15(6): 716-719. doi: https://doi.org/10.1097/mot.0b013e3283402beb
  2. Doxiadis,, II, Rahmel, A., Claas, F. H.: Towards kidney allocation on basis of HLA-DR compatibility. Clin Transpl, 2010; 61-64.
  3. Frans HJ Claas: Clinical relevance of circulating donor-specific HLA. Current Opinion in Organ Transplantation, 2010; 15(4): 462-466. doi: https://doi.org/10.1097/mot.0b013e32833b9c38

2009

  1. Frans HJ Claas, Ilias IN Doxiadis: Management of the highly sensitized patient. Current Opinion in Immunology, 2009; 21(5): 569-572. doi: https://doi.org/10.1016/j.coi.2009.07.010
  2. Ilias IN Doxiadis, Frans HJ Claas: Transplantation of highly sensitized patients via the acceptable mismatch program or desensitization? We need both. Current Opinion in Organ Transplantation, 2009; 14(4): 410-413. doi: https://doi.org/10.1097/mot.0b013e32832c433f
  3. Frans H. J. Claas, Axel Rahmel, IIias I. N. Doxiadis: Enhanced Kidney Allocation to Highly Sensitized Patients by the Acceptable Mismatch Program. Transplantation, 2009; 88(4): 447-45. doi: https://doi.org/10.1097/tp.0b013e3181b04a5f

2008

  1. Frans H. J. Claas: HLA antibody testing: a tool to facilitate not to prevent organ transplantation. International Journal of Immunogenetics, 2008; 35(4): 275-277. doi: https://doi.org/10.1111/j.1744-313X.2008.00800.x

2007

  1. C. Eijsink, Y. M. Zoet, M. J. Kardol, M. D. Witvliet, F. H. J. Claas, A. Mulder, I. I. N. Doxiadis: Identification of acceptable HLA mismatches in immunized patients using single-antigen-expressing cell lines. Tissue Antigens, 2007; 69(4): 354-357. doi: https://doi.org/10.1111/j.1399-0039.2007.00821.x
  2. Ilias I. N. Doxiadis, Johan W. de Fijter, Marko J. K. Mallat, Geert W. Haasnoot, Jan Ringers, Guido G. Persijn, Frans H. J. Claas: Simpler and equitable allocation of kidneys from postmortem donors primarily based on full HLA-DR compatibility. Transplantation, 2007; 83(9): 1207-1213. doi: https://doi.org/10.1097/01.tp.0000261108.27421.bc

2006

  1. Frans H.J. Claas, Dave L. Roelen, Arend Mulder, Ilias I.N. Doxiadis, Machteld Oudshoorn, Martin Heemskerk: Differential immunogenicity of HLA class I alloantigens for the humoral versus the cellular immune response: towards tailor-made HLA mismatching. Human Immunology, 2006; 67(6): 424-429. doi: https://doi.org/10.1016/j.humimm.2006.03.004
  2. Ilias I. N. Doxiadis, Frans H. J. Claas: Donor-Specific Antibodies Arising after Kidney Transplantectomy: Priming or Memory?. Transplantation, 2006; 81(4): 509-510. doi: https://doi.org/10.1097/01.tp.0000196714.25688.fd

2005

  1. Ilias IN Doxiadis, Rene J Duquesnoy, Frans HJ Claas: Extending options for highly sensitized patients to receive a suitable kidney graft. Current Opinion in Immunology, 2005; 17(5): 536-540. doi: https://doi.org/10.1016/j.coi.2005.07.010
  2. Frans H.J. Claas, Marlies K. Dankers, Machteld Oudshoorn, Jon J. van Rood, Arend Mulder, Dave L. Roelen, Rene J. Duquesnoy, Ilias I.N. Doxiadis: Differential immunogenicity of HLA mismatches in clinical transplantation. Transplant Immunology, 2005; 14(3): 187-191. doi: https://doi.org/10.1016/j.trim.2005.03.007
  3. Yvonne M. Zoet, Chantal Eijsink, Marrie J. Kardol, Marry E.I. Franke-van Dijk, G. Louis Wilson, Roel de Paus, Eric Mickelson, Mirjam Heemskerk, Peter J. van den Elsen, Frans H.J. Claas, Arend Mulder, Ilias I.N. Doxiadis: The single antigen expressing lines (SALs) concept: an excellent tool for screening for HLA-specific antibodies. Human Immunology, 2005; 66(5): 519-525. doi: https://doi.org/10.1016/j.humimm.2005.01.007
  4. Frans HJ Claas: Transplantation: changing dogmas in clinical transplantation immunology. Current Opinion in Immunology, 2005; 17(5): 533-535. https://doi.org/10.1016/j.coi.2005.07.008
  5. Yvonne M. Zoet, Chantal Eijsink, Radka Bohmova, Marian D. Witvliet, Marrie J. Kardol, Marry E. I. Franke, Frans H. J. Claas, Arend Mulder, Ilias I. N. Doxiadis: Single-Antigen-Expressing Cell Lines Are Excellent Tools for Detecting Human Leukocyte Antigen-C-Reactive Antibodies in Kidney Transplant Recipients. Transplantation, 2005; 79(9): 1268-1272. doi: https://doi.org/10.1097/01.tp.0000161246.33019.b6

2004

  1. Ilias I. N. Doxiadis, Jacqueline M. A. Smits, Guido G. Persijn, Ulrich Frei, Frans H. J. Claas: It takes six to boogie: Allocating cadaver kidneys in eurotransplant. Transplantation, 2004; 77(4): 615-617. doi: https://doi.org/10.1097/01.tp.0000103725.72023.d7
  2. Frans H. J. Claas, Marian D. Witvliet, Rene Duquesnoy, Guido G. Persijn, Ilias I. N. Doxiadis: The Acceptable Mismatch Program as a Fast Tool for Highly Sensitized Patients Awaiting a Cadaveric Kidney Transplantation: Short Waiting Time and Excellent Graft Outcome. Transplantation Journal, 2004; 78(2): 190-193. doi: https://doi.org/10.1097/01.tp.0000129260.86766.67
  3. Marlies K.A Dankers, Dave L Roelen, Nico J.D Nagelkerke, Peter de Lange, Guido G Persijn, Ilias I.N Doxiadis, Frans H.J Claas: The HLA-DR phenotype of the responder is predictive of humoral response against HLA class I antigens. Human Immunology, 2004; 65(1): 13-19. doi: https://doi.org/10.1016/j.humimm.2003.09.017
  4. Marlies K. A. Dankers, Marian D. Witvliet, Dave L. Roelen, Peter De Lange, Nelleke Korfage, Guido G. Persijn, René Duquesnoy, Ilias I.N. Doxiadis, Frans H.J. Claas: The number of amino acid triplet differences between patient and donor is predictive for the antibody reactivity against mismatched human leukocyte antigens. Transplantation, 2004; 77(8): 1236-1239. doi: https://doi.org/10.1097/01.tp.0000120385.03278.28

2003

  1. Marlies K.A. Dankers, Dave L. Roelen, Ellen M.W. van der Meer-Prins, Peter de Lange, Nelleke Korfage, Jacqueline M.A. Smits, Guido G. Persijn, Ken I. Welsh, Ilias I.N. Doxiadis, Frans H.J. Claas: Differential immunogenicity of HLA mismatches: HLA-A2 versus HLA-A28. Transplantation, 2003; 75(3): 418-420. doi: https://doi.org/10.1097/01.tp.0000044456.51462.e2
  2. Doxiadis,, II, Persijn, G. G., Claas, F. H.: The crossmatch policy of the transplantation center influences graft survival in cadaver kidney transplantation. Clin Transpl, 2003; 143-147.

2000

  1. Doxiadis,, II, Witvliet, M., Verduyn, W., de Lange, P., Tanke, J., Schreuder, G. M., Persijn, G. G., Claas, F. H.: The relevance of proficiency testing for laboratories involved in cadaveric organ transplantation and its consequences for graft survival. Clin Transpl, 2000; 99-103.

1999

  1. Claas, F. H., De Meester, J., Witvliet, M. D., Smits, J. M., Persijn, G. G., Doxiadis,, II: Acceptable HLA mismatches for highly immunized patients. Rev Immunogenet, 1999; 1(3): 351-358

1996

  1. Ilias IN Doxiadis, Jacqueline MA Smits, Geziena M Th Schreuder, Guido G Persijn, Hans C van Houwelingen, Jon J van Rood, Frans HJ Claas: Association between specific HLA combinations and probability of kidney allograft loss: the taboo concept. The Lancet, 1996; 348(1931): 850-853. doi: https://doi.org/10.1016/s0140-6736(96)02296-9

1989

  1. F. H. J. Claas, A. van Leeuwen, J. J. van Rood: Hyperimmunized patients do not need to wait for an HLA identical donor. Tissue Antigens, 1989; 34(10): 23-29. doi: https://doi.org/10.1111/j.1399-0039.1989.tb01713.x
  2. Claas, F. H., van Rood, J. J.: Transplantation in hyperimmunized patients. Adv Nephrol Necker Hosp, 1989; 18317-323.
  3. Frans H.J. Claas, Gijbels, Y., von Veen, A., de Waal, L. P., DAmaro, J., Persijn, G. G., van Rood, J. J.: Selection of cross-match negative HLA-A and/or -B mismatched donors for highly sensitized patients. Transplantation Proceedings, 1989; 21(1): 665-666.
  4. Frans H.J. Claas, de Waal, L. P., Beelen, J., Reekers, P., Berg-Loonen, P. V., de Gast, E., DAmaro, J., Persijn, G. G., Zantvoort, F., van Rood, J. J.: Transplantation of highly sensitized patients on the basis of acceptable HLA-A and B mismatches. Clin Transpl, 1989; 185-190.

1988

  1. F. Claas, Y Gijbels, J van der Velden-de Munck, J. van Rood: Induction of B cell unresponsiveness to noninherited maternal HLA antigens during fetal life. Science, 1988; 241(4874): 1815-1817. doi: https://doi.org/10.1126/science.3051377
  2. Frans H. J. Claas, Jon J. Rood: The hyperimmunized patient: from sensitization toward transplantation. Transplant International, 1988; 1(2): 53-57.
  3. Claas, F. H., Gijbels, Y., van der Velden-de Munck, J. J., de Waal, L. P., DAmaro, J., Hendriks, G. F., Persijn, G. G., van Rood, J. J.: A special strategy to increase the chance of finding cross-match negative kidneys for highly sensitized patients. Transplantation Proceedings, 1988; 20(5): 947-948.

1986

  1. Schreuder, G. M., Hendriks, G. F., DAmaro, J., Persijn, G. G.: An eight-year study of HLA typing proficiency in Eurotransplant. Tissue Antigens, 1986; 27(3): 131-141. doi: https://doi.org/10.1111/j.1399-0039.1986.tb01512.x

1985

  1. Hendriks, G. F., de Lange, P., DAmaro, J., Schreuder, G. M., Claas, F. H., Persijn, G. G., van Rood, J. J.: Eurotransplant experience with highly immunized patients. Scand J Urol Nephrol Suppl, 1985; 9281-86.
ETRL Publications - Eurotransplant